News & Events

PhD/HDR defense
17/06/2019 13h30
Stéphanie MAURIAC from Montcouquiol-Sans's lab will give a presentation entitled ...

from Montcouquiol-Sans's lab will give a presentation entitled ...
Date de la soutenance: 17/06/2019 - 13h30
Lieu: Neurocentre Magendie Seminar room

Hosted in the historic heart of Bordeaux, EUROGENESIS 4th conference will cover several aspects of adult neurogenesis function and its related pathologies. It aims to highlight the benefits of interdisciplinary research for gathering innovative knowledge in adult neural stem cells biology, and will promote new opportunities for cross-border disciplines interactions.

29/05/2019 10h00
Dana CONLISK from Deroche-Gamonet's lab will give a presentation entitled "Role of internal state on cocaine seeking in addiction vulnerable populations"

29/05/2019 10h30
Anes JU from Beyeler's lab will give a presentation entitled "Serotonin receptor expression of the insular cortex involved in anxiety"

03/05/2019 14h00
Dr. Julia Lemos, Dissecting the actions of CRF in the NAc
   Show the web article Link

Lieu: Amphi Centre Broca

Dr. Julia Lemos is an Assistant Professor at the Department of Neuroscience of the University of Minnesota (USA) and will present the work of her lab dissecting the actions of corticotropin releasing factor (CRF) in the nucleus accumbens.
Host: Anna Beyeler

Outside of its well-characterized actions in the HPA axis, the stress-associated peptide corticotropin-releasing factor (CRF) regulates neuronal excitability and synaptic transmission in several extrahypothalamic brain regions. Previous research has shown that CRF in the nucleus accumbens (NAc) promotes appetitive behavior through mechanisms that remain poorly understood. We have recently showed that CRF potentiates both dopaminergic and cholinergic transmission in the NAc. However, it is unknown how CRF regulates the activity of medium spiny neurons (MSNs), the principle projection neurons of the NAc, to modulate behavioral output. MSNs are classified by their peptide expression and projection targets within the basal ganglia: dMSNs form the direct projection pathway and express dynorphin, whereas iMSNs form the indirect pathway and express enkephalin. RNAscope in situ hybridization was used to assess Crh1 mRNA expression in MSN subpopulations, identifying dMSNs and iMSNs with expression of dynorphin (pdyn) or enkephalin (pEnk), respectively. 20% of all cells were positive for Crh1 mRNA, with approximately 30% co-expressing pEnk mRNA (iMSNs), 30% co-expressing pDyn mRNA (dMSNs) and 30% co-expressing neither marker. Using whole-cell patch clamp electrophysiology recordings in brain slices, we examined the function of exogenously-applied CRF on the excitability of MSNs in the NAc core. Application of 100 nM CRF produced a leftward shift in the current-voltage relationship, demonstrating that CRF can enhance the firing rate of both dMSNs and iMSNs. Next steps will focus on identifying the role of CRF receptor subtypes in enhancing the spiking activity in MSNs and elucidate whether this effect is through direct actions on MSNs or through dopaminergic and cholinergic modulation of MSNs.

Pour plus de détails:

The work of the Frick team was featured at a recent Simon's Foundation workshop exploring atypical sensory experience in autism

24/04/2019 10h00
Julien BOUREL from Oliet's lab will give a presentation entitled " "Role of the complement component C3 in memory deficits at the early stage of experimental multiple sclerosis"

24/04/2019 10h30
Bastien REDON from Marsicano's lab will give a presentation entitled ""Role of the endocannabinoid system in motivation for wheel running and palatable food"

A superb portrait of Ashley Castellanos Jankiewicz (Cota team) on the University of Bordeaux website.