News & Events






Seminars
16/05/2011 11h30
TOMITA Susumu

Lieu: Seminar room

(séries de conférence dans le cadre de l'IINS)
TOMITA Susumu (Yale University School of Medecine)



Hottopic
13/05/2011 12h00
Marion JALABERT Marion JALABERT from Daniel Choquet's IINS lab will present his project entitled 'Neuronal circuits underlying morphine action on dopamine neurons' Description Morphine is a highly potent analgesic with high addictive potential in specific contexts. Although dopamine neurons of the ventral tegmental area (VTA) are widely believed to play an essential role in the development of drug addiction, neuronal circuits underlying morphine action on dopamine neurons have not been fully elucidated. Here, we combined in vivo electrophysiology, tract-tracing experiment and targeted neuronal inactivation to dissect the neural circuit for morphine action on dopamine neurons in rats. First, we found that morphine targets in vivo the GABAergic tail of the ventral tegmental area, also called rostromedial tegmental nucleus, disrupting the balance between inhibition and excitation on dopamine neurons. Second, our data reveal that in the absence of VTA glutamatergic tone, there is no morphine-induced activation of dopamine neurons. We conclude that morphine excites dopamine neurons by simultaneous NMDA/AMPA receptor activation and cessation of GABA receptor activation.

Seminars
09/05/2011 11h30
Agnès Nadjar

Lieu: Seminar room

Vous êtes tous cordialement invités, étudiants, chercheurs, universitaires à assister à cette conférence de Laurent Gautron 'Vagal sensory neurons and energy balances' à l'Institut Magendie.
Une invitation d' Agnès Nadjar.

Pour plus de détails :
http://www.inb.u-bordeaux2.fr/siteneuro2/pages/Lundisemin/archisemin/archiSemin11/Gautron.php



Seminars
06/05/2011 10h00
Pr Silvia Arber

Lieu: Salle Magendie

Vous êtes tous cordialement invités, étudiants, chercheurs, universitaires à assister à cette conférence du Pr Silvia Arber 'Assembling neuronal circuits for movement' à l'Institut Magendie.
Une invitation de Sandrine Bertrand de l'INCIA

Pour plus de détails :
http://www.inb.u-bordeaux2.fr/siteneuro2/pages/Lundisemin/archisemin/archiSemin11/Arber.php



Hottopic
06/05/2011 12h00
Julien COURTIN Julien COURTIN from Piazza's lab will present his project entitled 'A subpopulation of prefrontal putative inhibitory interneurons controls conditioned fear expression'. Accumulating evidence indicate that the medial prefrontal cortex is necessary for conditioned fear expression. It is likely that neuronal changes occurring during fear expression depends on specific interactions between excitatory and inhibitory prefrontal microcircuits. However such microcircuits are still unknown. Recent anatomical and electrophysiological data indicate that cortical inhibitory circuits might regulate pyramidal cell activity at multiple levels. In order to evaluate the role of inhibitory prefrontal microcircuits during expression of conditioned fear responses we used single units recordings in behaving animals submitted to auditory fear conditioning. We found that a subpopulation of prefrontal putative inhibitory interneurons might selectively control conditioned fear expression.


Federico Massa had answer the questions of Yves Deris about his publication in PNAS.




Hottopic
29/04/2011 12h00
Matthias HABERL Matthias HABERL from Frick's lab will present his project entitled 'Neocortical circuitry in a model of mental retardation' The function of cortical circuits emerges from its anatomical wiring diagram and wiring defects are probably involved in a manyfold of neurological diseases. Still the detailed organization of the mammalian neocortex remains largely unknown and exceedingly difficult to investigate. Therefore cutting-edge tools that allow us to dissect the sub-circuits are inevitable. To study connectivity in the neocortex we are using viral tracing techniques, as lentivirus and rabies-based monosynaptic trans-synaptic tracing. We look at changes of connectivity in mental retardation, from fine scale microcircuits up to long ranging projections from the entire brain. We hope not just to learn more about importance of specific circuits in normal and diseased (Fragile X Syndrome) brain but also to understand more about the involvement of wiring defects in neurological diseases in general.

Seminars
26/04/2011 12h00
David DiGregorio

Lieu: Seminar room

Vous êtes tous cordialement invités, étudiants, chercheurs, universitaires à assister à cette conférence de David DiGregorio
'Spatio-temporal filtering of information flow by sublinear synaptic integration within thin dendrites' à l'Institut Magendie.

Pour plus de détails :
http://www.inb.u-bordeaux2.fr/siteneuro2/pages/Lundisemin/archisemin/archiSemin11/DiGregorio.php
Une invitation de Valentin Nagerl



Hottopic
22/04/2011 12h00
Yu ZHANG Yu ZHANG from Frick's lab will present his project entitled 'Pathophysiology of information processing in neocortical dendrites in Fragile X Syndrome' Fragile X Syndrome (FXS) is the most common form of inherited mental retardation syndrome, and it is caused by a silencing mutation of the gene Fmr1 (encoding the protein FMRP). In humans, the consequences of this disorder include hypersensitivity to sensory stimuli, autistic behavior, seizures, and learning and memory deficits. Channelopathies have not been addressed as a prominent feature of FXS, although several ion channel subunits are amongst the genes whose mRNAs are regulated by FMRP. These channels strongly regulate the active properties of dendrites and therefore dendritic information processing. We will probe ion channel dysfunction and its consequences for dendritic function in layer 5B pyramidal neurons of the whisker-related barrel cortex.

Hottopic
15/04/2011 12h00
Isabelle MATIAS Isabelle MATIAS from Marsicano's lab will present his project entitled 'Simultaneous Post-prandial Deregulation of the Orexigenic Endocannabinoid Anandamide and the Anorexigenic Peptide YY in Obesity'