Last news






Hottopic
28/11/2018 10h30
Marco MATOS from Oliet's lab will give a presentation entitled "Apolipoprotein E -ε4 in the development of synaptic impairment in Alzheimer's disease."

Seminars
27/11/2018 11h00
Abel Eraso Pichot (Autonomous University of Barcelona)

Lieu: Neurocentre Magendie Seminar room

- Adaptive regulation of calcium excitability and energy metabolism by CREB-dependent transcription in astrocytes: study of the mechanisms governing astrocyte plasticity

An increasing body of evidence suggests that astrocytes participate in higher-brain functions, controlling from synaptic transmission to global brain waves and learning and memory processes. Different mechanisms have been proposed to mediate these astrocyte-dependent processes, astrocytic lactate release and calcium-dependent gliotransmission being the main known effectors. The existence of control of brain functions by astrocytes suggests that astrocytes may shape brain functions in response to experience as much as neurons, thus constituting the phenomenon of astrocyte plasticity. In neurons, the transcription factor CREB is the best known coordinator of synaptic and intrinsic plasticity. The fact that, in astrocytes, CREB activation is also activity-dependent, positions CREB as an ideal target to promote plasticity-related changes in astrocytes, too. In this study, we have analyzed the effect of the activation of CREB-dependent transcription in astrocytes, specifically regarding calcium signals and metabolism. We have demonstrated that activation of CREB-dependent transcription reduces cytosolic calcium events via mitochondria and increases lactate release, which may have impact on synaptic transmission. An important contribution of the study is the molecular analysis of astrocytic mitochondria, which has revealed that astrocytes may use fuels other than glucose such as fatty acids to meet basic energy metabolic demands. Taken together, our results establish astrocytic CREB as a hub in astrocyte-plasticity and shed light on the interplay between plasticity and energy metabolism in astrocytes.




PhD/HDR defense
26/11/2018 14h00
Thomas KERLOCH A study on the development of granular neurons of the dentate gyrus: morphogenesis and regulation by Rnd2.

A study on the development of granular neurons of the dentate gyrus: morphogenesis and regulation by Rnd2.
Date de la soutenance: 26/11/2018 - 14h00
Lieu: Neurocentre Magendie Seminar room


PhD/HDR defense
22/11/2018 14h30
Arjun A-BHASKARAN Cellular and circuit mechanisms of neocortical dysfunction in Fragile X Syndrome

Cellular and circuit mechanisms of neocortical dysfunction in Fragile X Syndrome
Date de la soutenance: 22/11/2018 - 14h30
Lieu: Magendie Salle de conference


General informations
20/11/2018
Remittance of medals

Aude PANATIER receives her bronze medal from Nathalie Leresche (Charge de mission pour les Neurosciences, Institut des Sciences Biologiques du CNRS (INSB)) and Younis Hermés (Délégué Régional CNRS Aquitaine). more information here: https://youtu.be/D9BfK673oUE the video dedicates to Aude https://youtu.be/D9BfK673oUE





Collaboration Team Beyeler in Nature:
Dopamine modulates medial prefrontal cortex (mPFC) activity to mediate diverse behavioural functions. However, the precise circuit computations remain unknown. One potentially unifying model by which dopamine may underlie a diversity of functions is by modulating the signal-to-noise ratio in subpopulations of mPFC neurons. Here we demonstrate that dopamine increases the signal-to-noise ratio of responses to aversive stimuli in mPFC neurons projecting to the dorsal periaqueductal grey (dPAG). This data highlight how dopamine in the mPFC can selectively route sensory information to specific downstream circuits, representing a potential circuit mechanism for valence processing.




Seminars
13/11/2018 14h00
Jean-Sébastien Jouhanneau

Lieu: CGFB - Salle de conférence

Synaptic mechanisms of sparse firing





Lieu: Amphi du Centre Broca Nouvelle-Aquitaine

from Institut Curie (Paris) will give a presentation entitled 'Microtubule-based transport in radial glial progenitor cells'.
Monthly conference - PhD seminar series
Invitant : Bordeaux Neurocampus / NBA


Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2018/alexandre-baffet-phd-series.html


PhD/HDR defense
08/11/2018 14h00
Muriel KOEHL will support her HDR entitled: 'The Brain in the Making: The Place of Adult Neurognosis'

will support her HDR entitled: 'The Brain in the Making: The Place of Adult Neurognosis'
Date de la soutenance: 08/11/2018 - 14h00
Lieu: Neurocentre Magendie Seminar room


Hottopic
31/10/2018 10h00
Jerome EZAN from Montcouquiol-Sans's lab will give a presentation entitled 'Magendie Scientific life: why it is important to register to Hot-topics'