Agenda & Actualités







Lieu: Amphi du Centre Broca

Chef de groupe de l'Université Paris Descartes - Equipe Interactions Glie-Glie et Glie-Neurones dans le laboratoire de Neurophysiopathologie fera une présentation intitulée 'Contributions des astrocytes et de la signalisation satellite au traitement sensoriel'.


Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2018/cendra-agulhon.html



Lieu: Amphi du Centre Broca

from NIH- NIDA (Baltimore/USA)'s lab will give a presentation entitled 'Volitional social interaction prevents drug addiction in rat models'


Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2018/marco-venniro.html



Lieu: Amphi de la CGFB

from Department of Pharmacology & Systems Physiology (University of Cincinnati College of Medicine)'s lab will give a presentation entitled 'Molecular and neurophysiological pathways that promote microglia-mediated neuronal remodeling in response to chronic stress'


Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2018/eric-wohleb.html



Interview de Nora Abrous, Directeur de recherche à l'Inserm au Neurocentre Magendie à Bordeaux. Elle est notamment spécialiste en neurobiologie du développement, mémoire et système de mémoire, vieillissement cérébral, apprentissage, vulnérabilité et addictions. Elle dirige l'équipe "Neurogenèse et physiopathologie".
Émission autour du cerveau, de la mémoire et du vieillissement sur France Bleu





Lieu: CGFB Seminar room

from King's College, London / Centre for Developmental Neurobiology's lab will give a presentation entitled 'Mapping Synaptic Contacts: From Dendrites to the Axon Initial Segment'


Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2018/juan-burrone.html



Lieu: Amphi du Centre Broca

from Dean, Graduate College of Biomedical Sciences Western University of Health Sciences (Pomona, CA USA)'s lab will give a presentation entitled 'Opposite functions of calpain-1 and calpain-2 in the brain'

Invitant : Daniel Choquet, Team Leader: Dynamic organization & Function of synapses / Directeur de l'IINS


Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2018/michel-baudry.html



Le prochain congrès « Aging 2018 » se tiendra au domaine du Haut Carré à Talence du 26 au 28 septembre 2018. Il réunira les membres de la communauté neuroscientifique internationale autour d’un thème central : le vieillissement cognitif en absence de MA et l’existence de différences inter-individuelles dans l’atteinte mnésique au cours de l’âge.

Invitant : Bordeaux Neurocampus, Gwenaelle Catheline, Aline Marighetto, Nora Abrous
L’inscription est obligatoire pour toute personne participant ou assistant au Congrès. La soumission d’un abstract ne peut se faire qu’après inscription. Le colloque accueillera un maximum de 280 personnes. Les participants sont tenus d'être présents durant les 3 jours.






Beau succès pour le congrès Aging co-organisé par Nora Abrous, Aline Marighetto et Gwenaelle Catherine pour faire le point sur les dernières découvertes concernant le vieillissement cognitif.




Séminaire
25/09/2018 14h00
Sophie TRONEL

Lieu: Neurocentre Magendie Seminar room

Soutenance HDR: Sophie Tronel from Abrous's lab will give a presentation entitled 'Etude de la stabilisation de la mémoire'





Team “Neurogenesis and pathophysiology”. Neurocentre Magendie / Bordeaux Neurocampus:

The dentate gyrus (DG) of the hippocampus is one of the few mammalian brain structures where neurogenesis is maintained throughout the lifetime of individuals. Indeed the dentate granule cells (GCs), the main neuronal cell type in the DG, are generated via several distinct phases occurring during late embryogenesis, the early postnatal life, the juvenile period and throughout adulthood. Because of this continuous addition of new cells, the DG appears as a heterogeneous structure composed of different populations of granule neurons. Whether these different populations have similar or distinct structural and functional properties is still a matter of debate. Surprisingly, although most dentate GCs are generated during development, little was known about their properties compared to adult-born neurons. Nevertheless, it was generally admitted that these populations are morphologically indistinguishable once mature. However a detailed and extensive analysis of developmentally-born neurons was lacking for proper comparison.


In this study, we used in vivo electroporation to label dentate GCs generated in mouse embryos (E14.5) or in neonates (P0) and followed their morphological development up to 6 months after birth. Importantly, we highlight for the first time major morphological differences with GCs born during the juvenile period (P21) or during adulthood (P84). Importantly, we also identified different morphological parameters that can be used to predict the birthdate of granule neurons in adult brain sections. In addition, our data indicate that two other poorly studied populations of GCs in the DG, the semilunar and hilar granule cells are generated during the embryonic and the neonatal periods respectively. Thus, our findings provide new insights into the development of the different populations of granule neurons in the DG and open new questions regarding their function in the brain. Indeed, the dendritic tree determines the amount and specificity of inputs a neuron receives and is involved in sophisticated signal processing and neural computation. Consequently, mature dentate GCs born at embryonic, neonatal or adult stages might contribute differently to hippocampal function. Future analyses of the inputs and functional properties of the different populations of GCs using in vivo electroporation might help to address this controversial question.(Pictures : Thomas Kerloch, Nora Abrous, Emilie Pacary)

Dentate Granule Neurons Generated During Perinatal Life Display Distinct Morphological Features Compared With Later-Born Neurons in the Mouse Hippocampus. Thomas Kerloch, Solène Clavreul, Adeline Goron, Djoher Nora Abrous, Emilie Pacary. Cereb Cortex. 2018 Sep 12. doi: 10.1093/cercor/bhy224.