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Voilà plus de 15 ans que Giovanni Marsicano, responsable d’une équipe au Neurocentre Magendie (Bordeaux), se consacre à l'étude du système endocannabinoïde. En 2010, il a décroché un financement du Conseil européen de la recherche (ERC Starting Grant) pour comprendre son rôle dans la prise alimentaire. Ce point de départ l'a conduit bien au-delà...

Program Thursday 30th of March 2017

9:00 Opening
9:05 Nathalie Sans (Neurocentre Magendie, Bordeaux)
Presentation of the SYNAPTODIS network
9:15 Fabrizio Gardoni (University of Milano)
GluN2A-containing NMDARs: from physiological mechanisms to pathology
9:40 Camilla Bellone (University of Geneva)
Neuronal basis of social motivation hypothesis of Autism Spectrum Disorders
10:05 Nathalie Sans (Neurocentre Magendie, Bordeaux)
Planar cell polarity proteins and molecular mechanisms regulating excitatory synapses
10:30 Claudia Racca (University of Newcastle)
Electron microscopy applications to investigate cellular and synaptic structure and function in central neurons.
10:55 Coffee break

11:15 Carlo Sala (University of Milano)
Protein translation pathway in regulating neuronal network plasticity
11:40 Yoon Cho (INCIA, University of Bordeaux)
Neural information coding in synaptopathologies
12:05 Gregory Giannone (IINS, Bordeaux)
Nanoscale organization and dynamics of actin regulators in dendrtitic spines

12:30 Lunch

14:00 Michael Kreutz (LIN, University of Magdeburg)
The impact of the metabolic syndrome and high amyloid load on synaptic function
14:40 Anass Jawhari (Calixar, Lyon, France)
Native isolation and stabilization of membrane proteins for drug discovery : CALIXAR approach.
15:20 Johannes Krupp (Ipsen Innovation, Les Ullis, France)
Presentation of Ipsen / Development of Therapeutic Toxins: Towards A Recombinant Platform
16:00 Benjamin Hall (Roche Innovation Center Basel)
Presentation of Roche Pharma Research / A synapse and circuit based approach to drug development Early Development
16:40 Lars C.B. Ronn (Lundbeck Pharma A/S, Denmark)
Presentation of Lundbeck

BORDEAUX NEUROCAMPUS 15th SYNAPSE DAY Program Friday 31th of March 2017

9:00 Jeremy Henley (Center for Synaptic Plasticity, Bristol, UK)
Neuronal SUMOylation in health and disease
9:50 Julie Jezequel (IINS, University of Bordeaux)
NMDA receptor dysfunction in psychosis: non-canonical mechanism
10:10 Massimo Barresi (IMN, Bordeaux)
GPe neurons, a functional and immunohistochemical approach.

10.30-11.00 Coffee break

11:00 Agnès Nadjar (NutriNeurO, Bordeaux)
Early-life omega-3 modulate shaping of neuronal circuits by microglia.
11:40 Benjamin Robert (NCM, University of Bordeaux)
The Wnt/Planar cell polarity protein Vangl2 controls the DG-CA3 hipppocampal network
12:00 Mathieu Letellier (IINS, Bordeaux)
How to bring the right receptor to the right synapse: role of neuroligin phosphorylation in synapse specification.

12.30-14.00 lunch
14:00 Christophe Mulle (IINS, Bordeaux)
Subcellular segregation of glutamate receptors in hippocampal pyramidal neurons
14:50 Silvia Ciappelloni (Neurocentre Magendie, Bordeaux)
Trafficking of specific Aquaporin-4 isoforms bidirectionally regulate astrocyte process motility
15:10 Federico Soria (IMN, Bordeaux)
Unravelling the disorganisation of the extracellular space in the parkinsonian brain.
15.30 Balaz Rozna (Inst. of Exp. Medicine of the Hungarian Academy of Sciences)
Presentation of Fentonics / Fat3D Imaging of spine, dendritic and neuronal assemblies in behaving animals during visual learning
16:10 Matt Jones (School of Physiology and Pharmacology, Bristol, UK)
From place cells to pillows: linking psychiatric risk genes to neural networks in cognition and sleep.
17:00 The end…

"Diffusée par l’équipe Moncouquiol-Sans"

Info générale
Workshop: How to get more out of your behavioral data – tips and tricks
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Did you ever wish:
• To exchange with other behavioral scientists in an informal atmosphere?
• To learn more about the possibilities of EthoVision XT or other Noldus solutions?
• To see EthoVision XT in action in other research domains?
• To learn from other users, and see how they approach challenges like yours?
If the answer is yes, then we will be happy to meet you during the Noldus User Meeting at the Institut François Magendie,
on March 27th. This meeting will give you the possibility to meet other researchers, discuss your research projects, to get
practical information, and to learn how to exploit the full potential of Noldus solutions. Besides presentations, you will
have the possibility to get ‘hands-on’ experience with our systems during ‘ateliers’ (workshops) in small groups.

Diffusée par l'équipe Montcouquiol-Sans

24/03/2017 10h30
Dr. Karun Singh : How do Autism spectrum disorder risk genes impact brain development?
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How do Autism spectrum disorder risk genes impact brain development? One of the leading hypotheses is that risk genes disrupt the development of neural circuits. In the first part of my talk, I will go over our use of mouse models to study ASD risk genes and their role in synaptic development and dysfunction. In the final part, I will discuss our latest efforts to study in modeling ASD and synaptic function using gene editing of human neurons, and their potential use for drug discovery.
Selected publications
Kwan, V., Hung, C.L., White, S., Hoszapfel, N.T., Walker, S., Murtaza, N., Unda, B.K., Yuen, R.K.C., Habing, K., Milsom, C., Hope, K., Truant, R., Scherer, S.W. and Singh, K.K*. DIXDC1 phosphorylation and control of dendritic morphology is impaired by rare genetic variants.
Cell Reports 17(7):1892-1904. *corresponding author. PMID: 27829159

Unda, B.K., Kwan, V. and Singh, K.K*. (2016). Neuregulin-1 regulates cortical inhibitory neuron dendrite and synapse growth through DISC1.
Neural Plasticity, Article: 7694385. *corresponding author. PMID: 27847649

Lee, J.H#, Mitchell, R.R#., McNicol, J.D., Shapovalova, Z., Laronde, S., Tanasijevic, B., Milsom, C., Casado, F., Fiebig-Comyn, A., Collins, T.J., Singh, K.K., Bhatia M (2015). Single Transcription Factor Conversion of Human Blood Fate to NPCs with CNS and PNS Developmental Capacity.
Cell Reports. 11(9):1367-76. #equal contributions. PMID: 26004181.

Singh, K.K., Ge, X., Mao, Y., Drane, L., Meletis, K., Samuels, B.A. and Tsai, L.H. (2010). Dixdc1 is a critical regulator of DISC1 and embryonic cortical development. Neuron 67, 33-48. PMID: 20624590.

Scientific focus :
Dr. Karun Singh is an Investigator at the Stem Cell and Cancer Research Institute (SCCRI) and an Assistant Professor with the Department of Biochemistry and Biomedical Sciences at McMaster University, Canada since 2012. He holds the David Braley Chair in Human Stem Cell Research. He obtained his PhD from the University of Toronto and his postdoctoral training at the Massachusetts Institute of Technology (MIT) in USA. Currently, Dr. Singh's independent program employs a combination of mouse and patient-derived neural cellular models to study how genes associated with Autism spectrum disorders impact brain development. Currently his lab is focusing on 3 questions:

1. What is the normal role of ASD linked genes during mammalian brain development, with a particular emphasis on synaptic development?
2. How do ASD-linked genetic mutations impair brain (synaptic) development, from a biochemical to the functional perspective?
3. Is it possible to model neurodevelopmental disorders using human neuronal models, and use them for drug discovery?

Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2017/karun-singh.html

22/03/2017 12h00
Stephane VALERIO from Herry's lab will give a presentation entitled "The neural networks of fear conditioned analgesia"

Une vidéo de présentation de l'EquipEX Optopath et de certains thèmes de recherche qui y sont développés

08/03/2017 12h00
Thomas KERLOCH from Abrous's lab will give a presentation entitled "The RhoGTPase Rnd2 is critical for the survival and maturation of newly generated neurons in the adult hippocampus"

22/02/2017 12h00
Dylan POMMIER from Oliet's lab will give a presentation entitled "Astrocytic-dependent regulation of basal synaptic transmission depends on the number of activated neighboring synapses in adult rat."

Apply by March 20th to our 2nd Advanced Techniques for Synapse Biology, CAJAL Courses 2017!

Info générale
Cyril Herry récompensé

Cyril Herry est le lauréat 2016 du prix de l'Académie de Médecine dans la catégorie "avancée thérapeutique". Ce prix récompense son travail sur les substrats neuronaux du comportement de peur.