Neurocentre Magendie

Les publications

IF du Neurocentre

712 publications

* equal contribution
Les IF indiqués ont été collectés par le Web of Sciences en Juin 2016

29/09/1989 | Science   IF 34.7
Factors that predict individual vulnerability to amphetamine self-administration.
Piazza PV, Deminiere JM, Le Moal M, Simon H

Clinical observations show that there is considerable individual variability in the response to the addictive properties of drugs. This individual variability needs to be taken into account in animal models of addiction. Like humans, only some rats readily self-administer low doses of psychostimulants. The individual animals at risk can be identified on the basis of their response to environmental or pharmacological challenges. This predisposition to develop self-administration can be induced by repeated treatment with amphetamine. These results may help elucidate the neurobiological basis of addiction liability observed in both rats and humans.

09/1989 | Behav Neural Biol
The durations of hippocampal and cortical cholinergic activation induced by
Toumane A, Durkin T, Marighetto A, Jaffard R

Sodium-dependent high-affinity choline uptake velocities in P2 fractions of the

01/01/1989 | Behav Brain Res   IF 3
The influence of dopaminergic A10 neurons on the motor pattern evoked by substantia nigra (pars compacta) stimulation.
Piazza PV, Ferdico M, Russo D, Crescimanno G, Benigno A, Amato G

The influence of the mesolimbic-mesocortical dopaminergic (DA) system on the motor pattern evoked by substantia nigra pars compacta (SNpc) stimulation was studied. Electrical stimulation of the A10 group of neurons caused an inhibitory effect preferentially directed towards the orientation movement. Sulpiride administration at low dosages (50 mg/kg i.p.) did not modify this movement at the basal condition, but abolished the increase of its duration induced by ventral tegmental area (VTA) co-stimulation. Mesolimbic activation opposes the effects of SNpc stimulation, restraining the animal in its antero-posterior axis by means of orientation movement inhibition. The results suggest a role of the DA mesolimbic-mesocortical system in the maintenance of focused attention.

01/01/1989 | Behav Brain Res   IF 3
Circling behavior: ethological analysis and functional considerations.
Piazza PV, Ferdico M, Russo D, Crescimanno G, Benigno A, Amato G

Head-turning and circling movements evoked by substantia nigra (pars compacta) (SNpc) stimulation have been ethologically analyzed in order to attribute a functional meaning to these lateralization processes. It has been shown that these motor acts, separated by a constant interval, may be considered a fixed action pattern. The duration of the single acts depends on the SNpc stimulation parameters: the increase in the stimulus strength produces an increase in the number of turns but does not induce the disappearance of the orientation movement. The body movement is always preceded by the head-movement. Haloperidol administration induces a dose-related increase of the orientation component of the motor pattern. These data together with others in the literature suggest the participation of the SNpc in the mechanism of shift in the focus of attention from one point to another in the contralateral surrounding environment.

1989 | Arch Gerontol Geriatr Suppl   IF 1.4
Experimental dissociation of memory systems in mice: behavioral and neurochemical
Jaffard R, Durkin T, Toumane A, Marighetto A, Lebrun C

Evidence for different types of memory in mice may lead to development of animal

1989 | Neurosci Biobehav Rev   IF 7.8
Experimental approach to individual vulnerability to psychostimulant addiction.
Deminiere JM, Piazza PV, Le Moal M, Simon H

Vulnerability to the development of drug-intake has been studied by using the acquisition of intravenous amphetamine self-administration in the rat. In a series of neurobiological experiments we provoked imbalances in the functioning of the dopaminergic (DA) network by performing lesions of the DA cell bodies in the ventral tegmental area, DA terminals in the amygdala or median raphe nucleus. These imbalances which resulted in enhanced DA transmission ratio between the nucleus accumbens and the prefrontal cortex led to an increase in the rapidity of self-administration acquisition. With a psychobiological approach, we showed that individual differences in vulnerability to develop self-administration in rats of the same strain were correlated with locomotor responses to stress and to an acute injection of amphetamine. Moreover, activation of DA transmission by repeated amphetamine injections changed animals resistant to drug-intake into vulnerable ones. It is suggested that some inherited or acquired factors, at least in part by affecting the activity of DA network, can predispose individuals to drug abuse.

1989 | Ann N Y Acad Sci   IF 2.7
IFN-gamma is an essential cosignal for triggering IFN-beta 2/BSF-2/IL-6 gene expression in human monocytic cell lines.
Sanceau J, Beranger F, Gaudelet C, Wietzerbin J

10/1988 | Behav Brain Res   IF 3
Differential hippocampal and cortical cholinergic activation during the
Toumane A, Durkin T, Marighetto A, Galey D, Jaffard R

Possible differentiation of the intervention of cholinergic septohippocampal and

08/1988 | j interferon res
Interferon-beta 2 (BSF-2) mRNA is expressed in human monocytes.
Sanceau J, Falcoff R, Zilberstein A, Beranger F, Lebeau J, Revel M, Vaquero C

We previously have reported the presence of interferon-beta 2 (IFN-beta 2) mRNA in PHA-stimulated human peripheral blood leukocytes (PBL), as well as in nonstimulated cells, although at a lower level. The IFN-beta 2 cloned from a leukocyte library appeared to be similar to that of the fibroblast IFN-beta 2 gene first described in fibroblasts. To assess the nature of the cell population in which the synthesis of IFN-beta 2 takes place, PBL were fractionated in adherent and nonadherent cells. The antiviral activity of the culture supernatants of adherent cells was characterized as the IFN-beta type by neutralization with polyclonal antibodies raised against purified fibroblast IFN-beta 2. IFN-beta 2 mRNA was observed in enriched monocyte populations and accumulated very rapidly, peaking at 2.5 h. RNA extracted from these cultures encoded in a reticulocyte lysate a protein immunoprecipitated by the anti-IFN-beta 2 antiserum. In addition, IFN-beta 2 secreted in monocyte supernatants also was immunoprecipitated by the specific antiserum and was able to compete with the fibroblast IFN-beta 2, suggesting a strong similarity between the fibroblast and monocyte proteins.

Male rats received a dopaminergic implant aimed either at the nucleus accumbens or the ventral tegmental area (VTA) following 6-hydroxydopamine lesion of their mesocorticolimbic dopaminergic system. Exposure to electrical footshock stress 6 months later markedly activated the mesocorticolimbic neurons in control animals as shown by the increase of dihydroxyphenylacetic acid (DOPAC) levels both in the nucleus accumbens and the VTA. However, no stress-induced activation was seen for the grafted neurons, irrespective of the area of implantation. These results indicate the lack of reinnervation and modulation of the grafted dopaminergic neurons by one of the important afferent systems regulating the activity of endogenous mesencephalic dopaminergic neurons.