| Cereb Cortex IF 8.3 Activity-Dependent Neuroplasticity Induced by an Enriched Environment Reverses Cognitive Deficits in Scribble Deficient Mouse
Hilal ML, Moreau MM, Racca C, Pinheiro V, Piguel N, Santoni M-J, Dos santos carvalho S, Blanc JM, Abada Y, Peyroutou R, Medina C, Doat H, Papouin T, Vuillard L, Borg JP, Rachel R, Panatier A, Montcouquiol M*, Oliet SHR*, Sans N*
Planar cell polarity (PCP) signaling is well known to play a critical role during prenatal brain development; whether it plays
specific roles at postnatal stages remains rather unknown. Here, we investigated the role of a key PCP-associated gene
scrib in CA1 hippocampal structure and function at postnatal stages. We found that Scrib is required for learning and
memory consolidation in the Morris water maze as well as synaptic maturation and NMDAR-dependent bidirectional
plasticity. Furthermore, we unveiled a direct molecular interaction between Scrib and PP1/PP2A phosphatases whose
levels were decreased in postsynaptic density of conditional knock-out mice. Remarkably, exposure to enriched
environment (EE) preserved memory formation in CaMK-Scrib−/− mice by recovering synaptic plasticity and maturation.
Thus, Scrib is required for synaptic function involved in memory formation and EE has beneficiary therapeutic effects. Our
results demonstrate a distinct new role for a PCP-associated protein, beyond embryonic development, in cognitive
functions during adulthood.