Neurocentre Magendie

Yeri-Esther HIEN


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1 publication(s) depuis Septembre 2014:

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17/09/2014 | FEBS Lett   IF 3.5
CK2 accumulation at the axon initial segment depends on sodium channel Nav1.
Hien YE, Montersino A, Castets F, Leterrier C, Filhol O, Vacher H, Dargent B

Accumulation of voltage-gated sodium channel Nav1 at the axon initial segment (AIS), results from a direct interaction with ankyrin G. This interaction is regulated in vitro by the protein kinase CK2, which is also highly enriched at the AIS. Here, using phosphospecific antibodies and inhibition/depletion approaches, we showed that Nav1 channels are phosphorylated in vivo in their ankyrin-binding motif. Moreover, we observed that CK2 accumulation at the AIS depends on expression of Nav1 channels, with which CK2 forms tight complexes. Thus, the CK2-Nav1 interaction is likely to initiate an important regulatory mechanism to finely control Nav1 phosphorylation and, consequently, neuronal excitability.