Our group is investigating neuron-glia interactions with a particular interest for the tripartite synapse that considers astrocytes as active partners of chemical synapses.
The ability of astrocytes to ensure neurotransmitter uptake and to release gliotransmitters and their impact on synaptic transmission and synaptic plasticity has raised a lot of attention, identifying astroglial cells as possible targets to generate new and effective therapeutic strategies for brain diseases.
The general objective of our current research projects is to enhance our understanding of glial functions in healthy and diseased nervous system. We aim at characterize the impact of astrocytes on synaptic functions in physiological conditions as well as in the context of different pathologies like Alzheimer disease, multiple sclerosis, amyotrophic lateral sclerosis and addiction. To investigate glia-neurons interactions, we are using different physiological and pathological models in combination with the multidisciplinary approach available in our team like in vitro electrophysiology, morphological analysis, biochemical assays, state-of-the-art cell imaging and MRI.
More specifically, we are interested in deciphering the cellular mechanisms underlying gliotrasmission from detecting synaptic activity, identifying intracellular 2nd messenger pathways and defining independent domains of activity within individual astrocytes. We are also interested in analyzing fine anatomical morphological changes as well as monitoring membrane trafficking of key proteins. All these different glial-dependent process are investigated in regards of their impact onto synaptic transmission, synaptic plasticity, neuronal excitability, network activity and behaviour.En savoir
Memory impairment is an early and disabling manifestation of multiple sclerosis whose anatomical and biological substrates are still poorly understood. We thus investigated whether memory impairment e
Planar cell polarity (PCP) signaling is well known to play a critical role during prenatal brain development; whether it plays specific roles at postnatal stages remains rather unknown. Here, we inve
BACKGROUND: Cerebellar damage has been implicated in information processing speed (IPS) impairment associated with multiple sclerosis (MS) that might result from functional disconnection in the fronto
OBJECTIVE: We investigated whether diffusion tensor imaging (DTI) could reveal early hippocampal damage and clinically relevant correlates of memory impairment in persons with clinically isolated synd
Ketamine, a widely used anesthetic, has been shown to have NMDA receptor dependent and independent actions during zebrafish (Danio rerio) embryogenesis. Notwithstanding, the effects of developmental t