Obesity is a major health problem worldwide. However, despite the human and economic costs of this disease, efficient anti-obesity therapies are currently lacking.
One of the avenues that might lead to gain significant insights into the causes and potential treatments of obesity is the unravelling of the biological mechanisms regulating energy balance. Integrative systems and specific fuel sensing pathways are among the mechanisms known to control energy balance. Therefore, our past 4 years of research activity has been committed to studying in an integrated way both integrative systems and specific fuel sensing pathways. In particular, among the integrative systems, we have investigated the endogenous cannabinoid system (ECS) and, among the fuel sensing mechanisms, we have studied the mammalian Target Of Rapamycin complex 1 (mTORc1) cascade. Our studies on the ECS have helped to further detail the role of this system in energy balance by showing that while food intake and energy expenditure are controlled by cannabinoid receptors type 1 (CB1) located in the central nervous system, the equilibrium between energy storage and utilization is mediated by a direct action of CB1 on peripheral tissues. At the same time, our ground-breaking studies on the mTORc1 pathway have been the first to demonstrate that mTORc1 is a critical integrator of the effects of hormones and nutrients on food intake, and that the dysregulation of this pathway favours obesity.
Cell proliferation and neuroinflammation in the adult hypothalamus may contribute to the pathogenesis of obesity. Here we tested whether the intertwining of these two processes has a role in the metab
Cellular activity in the brain depends on the high energetic support provided by mitochondria, the cell organelles which use energy sources to generate ATP. Acute cannabinoid intoxication induces amne
Children with cerebral palsy have feeding difficulties that can contribute to undernutrition. The aim of this study was to investigate the effect of early undernutrition on locomotor activity and the
The endocannabinoid system (ECS) is an intercellular signalling mechanism that is present in the islets of Langerhans and plays a role in the modulation of insulin secretion and expansion of the beta-
Numerous epidemiological studies indicate that malnutrition during in utero development and/or childhood induces long-lasting learning disabilities and enhanced susceptibility to develop psychiatric d